The nuclear lamina is a hub for the nuclear function of Jacob
نویسندگان
چکیده
Abstract Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of and report prominent targeting envelope requires import. Immunogold electron microscopy proximity ligation assay combined with STED imaging revealed preferential association inner membrane where it directly binds LaminB1, an intermediate filament core component (INM). The INM transient; involves functional export signal in canonical CRM1-RanGTP-dependent mechanism defines residing time at INM. Taken together, data suggest stepwise redistribution within nucleus following import prior export.
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ژورنال
عنوان ژورنال: Molecular Brain
سال: 2021
ISSN: ['1756-6606']
DOI: https://doi.org/10.1186/s13041-020-00722-1